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Botox for the treating severe underarm sweating Botox, or botulinum toxin type A, is often referred to as a wrinkle treatment, but the U recently.S. Food and Medication Administration also authorized it for the treating serious underarm sweating, a debilitating condition known as major axillary hyperhidrosis. ‘Hyperhidrosis as a persistent condition that negatively impacts people’s standard of living and their capability to participate in normal function and social actions,’ says LA cosmetic surgeon Peter Fodor, MD, president of the 2200-member American Culture for Aesthetic COSMETIC SURGERY .